Description
[Brain natriuretic peptide 45]: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed: 2525380, PubMed: 9252368). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (By similarity). Likely involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, kaluresis and chloruresis (PubMed: 2525380, PubMed: 9252368)